How To Pass A Drug Test with Milk Thistle

Milk thistle has long been used in the treatment of different ailments. A new discovery claims that you can use milk thistle to pass a marijuana drug test.

Even though it is not a completely foolproof way of passing a drug test, some marijuana users claim that it works to achieve a positive outcome in a drug test for THC metabolites.

Here is everything you need to know about using milk thistle to pass a marijuana drug test.

Milk thistle

Also referred to as Silymarin, holy thistle or Mary thistle, milk thistle is a plant-based herb from the ragweed and daisy family. It grows in Mediterranean countries and is known for its medicinal qualities. White veins and flowers characterize its features.

How to pass a urine test using milk thistle

You will need:

  • Milk thistle extract pills – These are widely sold online and are available in different brands. It is advisable to go for the brand that has the Traditional Herbal Registration logo. Ensure it contains at least 80% of silymarin.
  • Vitamin B2 – This will give your urine the yellow color after it discolors due to the intake of too much water.
  • Test strips – these are used to test your urine and check whether it is clean enough for a test
  • You will need to carry out the milk thistle method at least 24 hours before the drug test. This gives you a higher chance of getting a clean urine sample.

The method:

  • Avoid using marijuana 24 hours before the test. This way, your system has a better chance of metabolizing THC metabolites before the test
  • Increase your intake of water as soon as you learn of a possible drug test. Ensure you pee whenever you feel the urge. Take at least a gallon of water within 24 hours. This will flush out as much of the THC metabolites as possible.
  • Take the milk thistle pills with every meal. The required dosage is three pills a day. If you have less than 24 hours before the test, you can take two pills at a go without risking an overdose.
  • Test your urine every few hours. This will tell you whether the method is working. The THC test strips show the level of THC in the sample. This makes it easy for you to decide on whether to up your milk thistle pills dose or your water intake.

On the day of the test:

Start your day early to ensure you have time for a cleansing regimen before the test. Take as much water as you can plus your milk thistle dosage.

Swallow another milk thistle pill at least 2 hours before the test plus the vitamin B2 pill. Continue taking your water.

How milk thistle helps to pass a urine marijuana drug test

Using milk thistle to pass a marijuana drug test involves the consumption of a lot of water. This works by reducing the THC metabolites concentration in your urine and thus increasing the chances of getting negative results for THC.
Apart from making you take a lot of water, milk thistle is also rich in Silymarin.

This is a group of active ingredients that make up 65% to 80% of milk thistle extracts. These active ingredients are claimed to have the ability to inhibit the activity of enzymes that metabolize drugs in the liver known as Cytochrome P450 and Uridine diphosphoglucuronosyl Transferase (CYP & UGT) enzymes.

How CYP & UGT enzymes work

CYP and UGT are the main liver enzymes needed to metabolize cannabinoids. For the effective breakdown of THC, the metabolization process occurs in two stages.

Stage 1: this process involves oxidization of active THC to 11-OH-THC, an active metabolite, which is further metabolized to THC-COOH, an inactive metabolite. This process is made possible by the CYP enzyme.

Stage 2: This is known as the glucuronidation phase that is facilitated by the UGT enzyme. In this phase, the glucuronide molecule is added to the THC-COOH metabolite. The end product of this process is THC-COO glucuronide. This is the metabolite form excreted through urine or stool.

Silymarin effect on the activity of the enzymes

Silymarin inhibits the activity of CYP, which slows down the rate at which THC is metabolized. Also, it inhibits the activity of the UGT enzymes, which slows down the glucuronidation process. This means that the amount of THC-COO-glucuronide released in urine or stool decreases. When the level of THC-COOH metabolites is lower, you stand a better chance of producing a clean urine sample for the test.

Milk Thistle Works to Inhibit CYP And UGT Enzymes – The Science Behind This Claim

For a long time, silymarin in milk thistle has been said to stop CYP enzyme activity and glucuronidation. This is how your body is able to produce a clean urine sample for a THC drug test. However, Science dictates that the liver is responsible for the outcome of any drug test. In light of this knowledge, a study was conducted to investigate the interaction of silymarin with marijuana.

This study also aimed to prove whether silymarin indeed inhibits the performance of the CYP and UGT enzymes in marijuana drug metabolism in the human liver.

For the study, the researchers obtained hepatocytes from the human liver and plated them six times on plates coated with rat-tail collagen. Some of the specimens were mildly treated with silymarin, some were not treated while others were treated with very high doses of silymarin.

The researchers examined the activity of CYP enzymes on hepatocytes. This was done by checking for the formation of the testosterone 6-BETA(OH) in the treated and untreated samples.

The results showed that the CYP enzyme was more active in the samples that were not treated with silymarin, lower in the mildly treated samples, and almost inactive in the samples treated with high doses of silymarin.

The researchers went further and assessed the activity of the UGT enzyme by assessing the formation of 4-methylumbelliferone glucuronide (4-MUG). Based on the results, untreated liver cells formed 4-MUG at a higher rate as compared to cells that were silymarin treated.

Does it work?

Based on scientific research, milk thistle can help to get a negative result on a marijuana test. Even so, this is a 2-in-1 method if you want to pass the test. You minimize the creating of THC-COOH metabolites while at the same time using water to dilute the THC metabolites traces in your urine.

This 2-in-1 formula may be a bit too strenuous for most marijuana smokers, and it requires you to avoid stoning at least 24 hours before the test. This may not be possible for most users. Also, overdiluting your urine reduces the level of creatinine and specific urine gravity. This is a red flag in urine drug tests and can render your sample unviable.

If you want a more reliable solution, the use of detox kits such as the same day Fast Marijuana Detox Kit or the Premium 7 Day Detox Kit is an easier option of ensuring you test negative for marijuana in a urine drug test.

As the names indicate, the Fast Marijuana Detox Kit is a solution that starts to cleanse your system of THC metabolites immediately you start using it. You can use this kit for same-day negative THC drug test results. You can take it an hour before your drug test and still pass.

If you require a long-term solution, a product like the Premium 7 Day Detox Kit can cleanse your system of THC metabolites in seven days.

Using detox kits gives you a better chance of getting a negative result for THC metabolites faster, without going into the trouble of taking too much water, foregoing your daily smoke or overdiluting your urine.